The treatment is performed with 2 injections with an interval of 1 week. Why this is the optimum number for the treatment? What about doing more injections?The clinical study results were obtained after 2 injections. We believe that the optimum results can be seen if the full therapeutic cycle is followed (that is, 2 injections with an interval of 1 week).
Additional administrations of SportVis™ during follow up assessments can be done, since SportVis™ contains STABHA™ (biocompatible Hyaluronic Acid).
Could you specify the place and way of injection?Injections were be administered into the soft tissue 1 cm from the lateral epicondyle at the point of greatest pain in two planes using a fanning technique whereby contents were injected on withdrawal of the needle from the point of maximal tenderness in a single puncture.
How does SportVis™ work?SportVis™’s main ingredient is STABHA™ (Soft Tissue Adapted Biocompatible Hyaluronic Acid).
Once STABHA™ is introduced to the site, it performs the following activities:
- It reacts with cellular fibronectin to create a scaffold which facilitates and controls the cellular migration at the injury site. This scaffold is able to promote healing as it acts as a barrier by limiting the access of macrophages and lymphocytes to this site.
- STABHA™ is also helps in re-organising the fibrils in fibres and fascicles as well as restoring the fibres into their normal parallel arrangement.
- STABHA™ provides the injury site structural support as well as acts as a healing component.
STABHA™ which is contained in SportVis™ is believed to increase the quality of healing thus reducing scar tissue formation.
It was shown in the clinical study that patients using SportVis™ went back to their daily activities within a specific amount of time 18 (±11) days whereas this was not seen in the control group.
SportVis™ is an effective and efficient method of quantitative and qualitative management of epicondylitis. Results from using SportVis™ show that benefits have been seen even 1 year later.
What is the manufacturing process of SportVis™?SportVis™ is produced by an innovative manufacturing process which is patented. SportVis™ is derived from continuous fermentation of Streptococcus equi.
After fermentation, the biomass is separated from the solution by filtration to obtain a cell-free solution. This solution is then purified by diafiltration to remove low molecular weight impurities (those derived from the production organism’s metabolism, the residual components of the nutrient medium).
The precipitation of nucleic acids and endotoxins is obtained by the addition of a cationic surfactant.
This results in a purity profile that allows SportVis™ to be biocompatible with soft tissues.
What is the molecular weight of SportVis™?Molecular weight is not the focal point of SportVis™ specific target. SportVis™ design was focused specifically using a very carefully selected set of parameters that gives the optimal rheological properties, thus residence time in the soft tissue.
Purity is also another key factor instead of molecular weight. Both the purity profile and ideal residence time in the soft tissue allows SportVis™ to achieve maximum interactions with torn ligaments and tendons.